Rifampicin and vitamin D metabolism
MJ Brodie, AR Boobis, CT Dollery… - Clinical …, 1980 - Wiley Online Library
MJ Brodie, AR Boobis, CT Dollery, CJ Hillyard, DJ Brown, I Maclntyre, BK Park
Clinical Pharmacology & Therapeutics, 1980•Wiley Online LibraryA 2‐wk course of rifampicin orally (600 mg/day) in 8 male subjects resulted in a consistent
fall in plasma 25‐hydroxycholecalciferol (25‐OHD) levels of around 70%, accompanied by
increased oxidation of antipyrine and 6β‐hydroxycortisol (indicative of hepatic enzyme
induction). Plasma levels of 1, 25‐dihydroxycholecalciferol, parathyroid hormone, and
calcitonin were not altered. The fall in 25‐OHD may represent the earliest lesion of drug‐
induced osteomalacia. Clinical Pharmacology and Therapeutics (1980) 27, 810–814; doi …
fall in plasma 25‐hydroxycholecalciferol (25‐OHD) levels of around 70%, accompanied by
increased oxidation of antipyrine and 6β‐hydroxycortisol (indicative of hepatic enzyme
induction). Plasma levels of 1, 25‐dihydroxycholecalciferol, parathyroid hormone, and
calcitonin were not altered. The fall in 25‐OHD may represent the earliest lesion of drug‐
induced osteomalacia. Clinical Pharmacology and Therapeutics (1980) 27, 810–814; doi …
A 2‐wk course of rifampicin orally (600 mg/day) in 8 male subjects resulted in a consistent fall in plasma 25‐hydroxycholecalciferol (25‐OHD) levels of around 70%, accompanied by increased oxidation of antipyrine and 6β‐hydroxycortisol (indicative of hepatic enzyme induction). Plasma levels of 1,25‐dihydroxycholecalciferol, parathyroid hormone, and calcitonin were not altered. The fall in 25‐OHD may represent the earliest lesion of drug‐induced osteomalacia.
Clinical Pharmacology and Therapeutics (1980) 27, 810–814; doi:10.1038/clpt.1980.115
Wiley Online Library