[HTML][HTML] Effects of nonlipolytic ligand function of endothelial lipase on high density lipoprotein metabolism in vivo
UC Broedl, C Maugeais, D Marchadier, JM Glick… - Journal of Biological …, 2003 - ASBMB
Endothelial lipase (EL) influences high density lipoprotein (HDL) metabolism in vivo and
mediates bridging and uptake of HDL particles independent of its lipolytic activity in vitro. To
determine whether EL has a nonlipolytic ligand function in HDL metabolism in vivo, 1× 10 11
particles of a recombinant adenovirus encoding human EL (AdEL), catalytically inactive
human EL (AdEL S149A), or control (Adnull) were injected into wild-type, apoA-I transgenic,
and hepatic lipase knockout mice. EL S149A protein was expressed at higher levels than …
mediates bridging and uptake of HDL particles independent of its lipolytic activity in vitro. To
determine whether EL has a nonlipolytic ligand function in HDL metabolism in vivo, 1× 10 11
particles of a recombinant adenovirus encoding human EL (AdEL), catalytically inactive
human EL (AdEL S149A), or control (Adnull) were injected into wild-type, apoA-I transgenic,
and hepatic lipase knockout mice. EL S149A protein was expressed at higher levels than …