[PDF][PDF] Hierarchy of the β‐cell signals controlling insulin secretion
JC Henquin, MA Ravier, M Nenquin… - European journal of …, 2003 - academia.edu
European journal of clinical investigation, 2003•academia.edu
The main function of pancreatic β cells is to synthesize and secrete insulin at appropriate
rates to limit blood glucose fluctuations within a narrow range. Any alteration in β-cell
functioning has a profound impact on glucose homeostasis: excessive secretion of insulin
causes hypoglycaemia, and insufficient secretion leads to diabetes. It is therefore not
surprising that insulin secretion is subject to very tight control. This control is primarily
ensured by glucose itself but also involves an array of metabolic, neural, hormonal and …
rates to limit blood glucose fluctuations within a narrow range. Any alteration in β-cell
functioning has a profound impact on glucose homeostasis: excessive secretion of insulin
causes hypoglycaemia, and insufficient secretion leads to diabetes. It is therefore not
surprising that insulin secretion is subject to very tight control. This control is primarily
ensured by glucose itself but also involves an array of metabolic, neural, hormonal and …
The main function of pancreatic β cells is to synthesize and secrete insulin at appropriate rates to limit blood glucose fluctuations within a narrow range. Any alteration in β-cell functioning has a profound impact on glucose homeostasis: excessive secretion of insulin causes hypoglycaemia, and insufficient secretion leads to diabetes. It is therefore not surprising that insulin secretion is subject to very tight control. This control is primarily ensured by glucose itself but also involves an array of metabolic, neural, hormonal and sometimes pharmacological factors (Fig. 1). To integrate all these stimulatory and inhibitory influences, β cells rely on an astonishingly complex stimulus-secretion coupling. This review discusses how the hierarchy between two intracellular pathways, producing triggering and amplifying signals [1], optimizes adequate insulin secretion to changes in blood glucose concentration and enables the β cell to grade the numerous extracellular messages that it receives.
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