Asymmetric cell division: fly neuroblast meets worm zygote

CQ Doe, B Bowerman - Current opinion in cell biology, 2001 - Elsevier
Current opinion in cell biology, 2001Elsevier
Both Drosophila neuroblasts and Caenorhabditis elegans zygotes use a conserved protein
complex to establish cell polarity and regulate spindle orientation. Mammalian epithelia also
use this complex to regulate apical/basal polarity. Recent results have allowed us to
compare the mechanisms regulating asymmetric cell division in Drosophila neuroblasts and
the C. elegans zygote.
Both Drosophila neuroblasts and Caenorhabditis elegans zygotes use a conserved protein complex to establish cell polarity and regulate spindle orientation. Mammalian epithelia also use this complex to regulate apical/basal polarity. Recent results have allowed us to compare the mechanisms regulating asymmetric cell division in Drosophila neuroblasts and the C. elegans zygote.
Elsevier