Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells.
LA Selbie, C Schmitz-Peiffer, Y Sheng… - Journal of Biological …, 1993 - ASBMB
The protein kinase C (PKC) family of serine-threonine kinases comprises at least eight
members. These are differentially expressed, show varying affinities for activators such as
Ca2+ and lipid species, and are therefore thought to play wide-ranging roles in the
regulation of such cellular processes as differentiation, growth, and secretion. The aim of this
study was to identify new PKC isoforms in the insulin-secreting cell line RINm5F that might
be activated by the alterations in lipid metabolism that accompany nutrient-stimulated insulin …
members. These are differentially expressed, show varying affinities for activators such as
Ca2+ and lipid species, and are therefore thought to play wide-ranging roles in the
regulation of such cellular processes as differentiation, growth, and secretion. The aim of this
study was to identify new PKC isoforms in the insulin-secreting cell line RINm5F that might
be activated by the alterations in lipid metabolism that accompany nutrient-stimulated insulin …