Xanthine derivatives as adenosine receptor antagonists
BB Fredholm, CGA Persson - European journal of pharmacology, 1982 - Elsevier
BB Fredholm, CGA Persson
European journal of pharmacology, 1982•ElsevierThe potency of a series of xanthine derivatives as adenosine antagonists was studied in fat
cells (A 1-receptors) and hippocampal slices (A 2-receptors) and on L-[3 H]
phenylisopropyladenosine (PIA) binding in membranes from rat cortex. The order of potency
in all three tests systems was: diethyl-8-phenyl-theophylline 8-phenyltheophylline 8-p-
sulfophenyltheophylline verrophylline isobutlmethylxanthine theophylline caffeine
theobromine. Enprofylline was about 20 times more potent in the hippocampus system than …
cells (A 1-receptors) and hippocampal slices (A 2-receptors) and on L-[3 H]
phenylisopropyladenosine (PIA) binding in membranes from rat cortex. The order of potency
in all three tests systems was: diethyl-8-phenyl-theophylline 8-phenyltheophylline 8-p-
sulfophenyltheophylline verrophylline isobutlmethylxanthine theophylline caffeine
theobromine. Enprofylline was about 20 times more potent in the hippocampus system than …
Abstract
The potency of a series of xanthine derivatives as adenosine antagonists was studied in fat cells (A1-receptors) and hippocampal slices (A2-receptors) and on L-[3H]phenylisopropyladenosine (PIA) binding in membranes from rat cortex. The order of potency in all three tests systems was:diethyl-8-phenyl-theophylline 8-phenyltheophylline 8-p-sulfophenyltheophylline verrophylline isobutlmethylxanthine theophylline caffeine theobromine. Enprofylline was about 20 times more potent in the hippocampus system than in the other two systems.
Elsevier