Three isoforms of platelet-derived growth factors all have the capability to induce angiogenesis in vivo
T OIKAWA, C ONOZAWA, M SAKAGUCHI… - Biological and …, 1994 - jstage.jst.go.jp
T OIKAWA, C ONOZAWA, M SAKAGUCHI, I Morita, S MUROTA
Biological and Pharmaceutical Bulletin, 1994•jstage.jst.go.jpThree isoforms of platelet-derived growth factors (PDGFs) composing of AA, AB and BB
chains all exhibited angiogenic activity in a dose-dependent manner in an in vivo assay
system involving the chorioallantoic membrane of chick embryo. The order of potency was
BB> AB= AA. They, however, failed to stimulate proliferation of vascular endothelial cells,
suggesting that their effects are indirect. These data suggest the possibility that three PDGF
isoforms are indirect angiogenic factors.
chains all exhibited angiogenic activity in a dose-dependent manner in an in vivo assay
system involving the chorioallantoic membrane of chick embryo. The order of potency was
BB> AB= AA. They, however, failed to stimulate proliferation of vascular endothelial cells,
suggesting that their effects are indirect. These data suggest the possibility that three PDGF
isoforms are indirect angiogenic factors.
Three isoforms of platelet-derived growth factors (PDGFs) composing of AA, AB and BB chains all exhibited angiogenic activity in a dose-dependent manner in an in vivo assay system involving the chorioallantoic membrane of chick embryo. The order of potency was BB> AB= AA. They, however, failed to stimulate proliferation of vascular endothelial cells, suggesting that their effects are indirect. These data suggest the possibility that three PDGF isoforms are indirect angiogenic factors.
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