[HTML][HTML] Protective role of interleukin-1 in mycobacterial infection in IL-1 α/β double-knockout mice
H Yamada, S Mizumo, R Horai, Y Iwakura… - Laboratory …, 2000 - Elsevier
To understand the role of the proinflammatory cytokine interleukin-1 (IL-1) in mycobacterial
inflammation, IL-1 α/β double-knockout (KO) mice were produced. These mice were infected
with either Mycobacterium tuberculosis H37Rv by the airborne route using an airborne
infection apparatus, and their capacities to control mycobacterial growth, granuloma
formation, cytokine, and nitric oxide (NO) production were examined. The IL-1 α/β mice
developed significantly larger (p< 0.01) granulomatous, but not necrotic, lesions in their …
inflammation, IL-1 α/β double-knockout (KO) mice were produced. These mice were infected
with either Mycobacterium tuberculosis H37Rv by the airborne route using an airborne
infection apparatus, and their capacities to control mycobacterial growth, granuloma
formation, cytokine, and nitric oxide (NO) production were examined. The IL-1 α/β mice
developed significantly larger (p< 0.01) granulomatous, but not necrotic, lesions in their …