Dynamics of tumor cell killing by human T lymphocytes armed with an anti-carcinoembryonic antigen chimeric immunoglobulin T-cell receptor
EJ Beecham, S Ortiz-Pujols… - Journal of …, 2000 - journals.lww.com
Chimeric immunoglobulin T-cell receptors (IgTCR) join the antigen-binding portion of an
antibody to one of the signaling chains of the TCR. A previous report described the
construction and functional testing of an IgTCR gene directed against the carcinoembryonic
tumor antigen (CEA). These preclinical studies showed the proper assembly and cell
surface expression of anti-CEA IgTCR molecules, specific target antigen binding, and
activation of T-cell effector functions. Although IgTCR-modified T cells function well in vitro …
antibody to one of the signaling chains of the TCR. A previous report described the
construction and functional testing of an IgTCR gene directed against the carcinoembryonic
tumor antigen (CEA). These preclinical studies showed the proper assembly and cell
surface expression of anti-CEA IgTCR molecules, specific target antigen binding, and
activation of T-cell effector functions. Although IgTCR-modified T cells function well in vitro …