Lentiviral vectors for the treatment of neurodegenerative diseases.
E Martin-Rendon, M Azzouz… - Current opinion in …, 2001 - europepmc.org
E Martin-Rendon, M Azzouz, ND Mazarakis
Current opinion in molecular therapeutics, 2001•europepmc.orgA number of potential gene therapy applications in the adult nervous system include
neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease and
amyotrophic lateral sclerosis. During the last five years, lentiviral vectors have developed
into extremely efficient gene transfer vehicles to the nervous system, revealing a wide range
of possibilities for the treatment or such disorders. This review describes the most important
and recent advances in the development of lentiviral vectors as well as the demonstration of …
neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease and
amyotrophic lateral sclerosis. During the last five years, lentiviral vectors have developed
into extremely efficient gene transfer vehicles to the nervous system, revealing a wide range
of possibilities for the treatment or such disorders. This review describes the most important
and recent advances in the development of lentiviral vectors as well as the demonstration of …
A number of potential gene therapy applications in the adult nervous system include neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis. During the last five years, lentiviral vectors have developed into extremely efficient gene transfer vehicles to the nervous system, revealing a wide range of possibilities for the treatment or such disorders. This review describes the most important and recent advances in the development of lentiviral vectors as well as the demonstration of proof-of-principle in animal models of human neurodegenerative diseases.
europepmc.org