[HTML][HTML] Matrix regulation of skeletal cell apoptosis: role of calcium and phosphate ions
CS Adams, K Mansfield, RL Perlot… - Journal of Biological …, 2001 - ASBMB
Previously, we noted that inorganic phosphate (P i), a major component of bone
extracellular matrix, induced osteoblast apoptosis (Meleti, Z., Shapiro, IM, and Adams, CS
(2000) Bone (NY) 27, 359–366). Since Ca 2+ along with P i is released from bone during the
resorption process, we advanced the hypothesis that Ca 2+ modulates P i-mediated
osteoblast apoptosis. To test this hypothesis, osteoblasts were incubated with both ions, and
cell death was determined. We noted that a modest increase in the medium Ca 2+ …
extracellular matrix, induced osteoblast apoptosis (Meleti, Z., Shapiro, IM, and Adams, CS
(2000) Bone (NY) 27, 359–366). Since Ca 2+ along with P i is released from bone during the
resorption process, we advanced the hypothesis that Ca 2+ modulates P i-mediated
osteoblast apoptosis. To test this hypothesis, osteoblasts were incubated with both ions, and
cell death was determined. We noted that a modest increase in the medium Ca 2+ …