[HTML][HTML] Activation of caspases is required for osteoblastic differentiation
M Mogi, A Togari - Journal of Biological Chemistry, 2003 - ASBMB
Previous studies have shown that mouse osteoblastic MC3T3-E1 cells undergo apoptosis
when exposed to a mixture of proinflammatory cytokines. Bone morphogenetic protein
(BMP) s are important regulators of osteoblast differentiation. Because regulation of
osteoblastic differentiation is poorly understood, we sought to determine if BMP-4-induced
differentiation of osteoblastic cells depends on the activity of the key apoptotic proteases, ie
the caspases. BMP-4 induced the growth arrest and differentiation of osteoblastic cell line …
when exposed to a mixture of proinflammatory cytokines. Bone morphogenetic protein
(BMP) s are important regulators of osteoblast differentiation. Because regulation of
osteoblastic differentiation is poorly understood, we sought to determine if BMP-4-induced
differentiation of osteoblastic cells depends on the activity of the key apoptotic proteases, ie
the caspases. BMP-4 induced the growth arrest and differentiation of osteoblastic cell line …