Acute regulation of proximal tubule apical membrane Na/H exchanger NHE-3: role of phosphorylation, protein trafficking, and regulatory factors
OW Moe - Journal of the American Society of Nephrology, 1999 - journals.lww.com
The mammalian proximal tubule reabsorbs approximately 80% of the NaHCO3 and
approximately 50% of the filtered NaCl from the glomerular filtrate (1–3). All of the
transcellular NaCl and two-thirds of the transcellular NaHCO3 absorption are mediated by
the proximal tubule apical membrane Na/H exchanger (4, 5). In addition, transcellular
NaHCO3 absorption also provides the driving force for paracellular NaCl absorption (6).
Quantitatively, this translates to severalfold of the total extracellular NaCl and NaHCO3 …
approximately 50% of the filtered NaCl from the glomerular filtrate (1–3). All of the
transcellular NaCl and two-thirds of the transcellular NaHCO3 absorption are mediated by
the proximal tubule apical membrane Na/H exchanger (4, 5). In addition, transcellular
NaHCO3 absorption also provides the driving force for paracellular NaCl absorption (6).
Quantitatively, this translates to severalfold of the total extracellular NaCl and NaHCO3 …