Increased endothelin activity mediates augmented distal nephron acidification induced by dietary protein
A Khanna, J Simoni, C Hacker… - Journal of the American …, 2004 - journals.lww.com
The hypothesis that increased dietary protein augments distal nephron acidification and
does so through an endothelin (ET-1)-dependent mechanism was tested. Munich-Wistar rats
that ate minimum electrolyte diets of 50%(HiPro) and 20%(CON) casein-provided protein,
the latter comparable to standard diet, were compared. HiPro versus CON had higher distal
nephron net HCO 3 reabsorption by in vivo microperfusion (37.8±3.2 versus 16.6±1.5
pmol/mm per min; P< 0.001) as a result of higher H+ secretion (41.3±4.0 versus 23.0±2.1 …
does so through an endothelin (ET-1)-dependent mechanism was tested. Munich-Wistar rats
that ate minimum electrolyte diets of 50%(HiPro) and 20%(CON) casein-provided protein,
the latter comparable to standard diet, were compared. HiPro versus CON had higher distal
nephron net HCO 3 reabsorption by in vivo microperfusion (37.8±3.2 versus 16.6±1.5
pmol/mm per min; P< 0.001) as a result of higher H+ secretion (41.3±4.0 versus 23.0±2.1 …