Immunoglobulin Production Induced by CD57+ GC-Derived Helper T Cellsin VitroRequires Addition of Exogenous IL-2
E Andersson, K Dahlenborg, M Ohlin… - Cellular …, 1996 - Elsevier
Germinal centers (GC) are well-defined areas in lymphoid organs were B cells proliferate
and differentiate in response to T-cell-dependent antigens. The GC comprises B cells,
follicular dendritic cells, tangible body macrophages, and a low number of CD4+ T cells. A
large portion of these T cells expresses CD57. We have examined the ability of the CD4+
CD57+ GC T cells to become activated and to take part in B cell activation processes. These
T cells coexpress CD45RO, CD69, CD28, and upon mitogenic stimulation CD25. The cell …
and differentiate in response to T-cell-dependent antigens. The GC comprises B cells,
follicular dendritic cells, tangible body macrophages, and a low number of CD4+ T cells. A
large portion of these T cells expresses CD57. We have examined the ability of the CD4+
CD57+ GC T cells to become activated and to take part in B cell activation processes. These
T cells coexpress CD45RO, CD69, CD28, and upon mitogenic stimulation CD25. The cell …