Calpain inhibitors, a treatment for Alzheimer's disease: position paper
F Battaglia, F Trinchese, S Liu, S Walter… - Journal of Molecular …, 2003 - Springer
F Battaglia, F Trinchese, S Liu, S Walter, RA Nixon, O Arancio
Journal of Molecular Neuroscience, 2003•SpringerCalpains modulate processes that govern the function and metabolism of proteins key to the
pathogenesis of Alzheimer's disease, including tau and amyloid precursor protein. Because
activation of the calpain system might contribute to the impairment of synaptic transmission
in Alzheimer's disease, we are currently testing the hypotheses that a treatment with calpain
inhibitors might restore normal cognition and synaptic transmission in a transgenic model of
Alzheimer's disease, the APP (K670N: M671L)/PS1 (M146L) mouse. Findings derived from …
pathogenesis of Alzheimer's disease, including tau and amyloid precursor protein. Because
activation of the calpain system might contribute to the impairment of synaptic transmission
in Alzheimer's disease, we are currently testing the hypotheses that a treatment with calpain
inhibitors might restore normal cognition and synaptic transmission in a transgenic model of
Alzheimer's disease, the APP (K670N: M671L)/PS1 (M146L) mouse. Findings derived from …
Abstract
Calpains modulate processes that govern the function and metabolism of proteins key to the pathogenesis of Alzheimer’s disease, including tau and amyloid precursor protein. Because activation of the calpain system might contribute to the impairment of synaptic transmission in Alzheimer’s disease, we are currently testing the hypotheses that a treatment with calpain inhibitors might restore normal cognition and synaptic transmission in a transgenic model of Alzheimer’s disease, the APP (K670N:M671L)/PS1(M146L) mouse. Findings derived from these studies will provide a novel approach to cognitive enhancement in Alzheimer’s disease.
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