[HTML][HTML] The nuclear receptors peroxisome proliferator-activated receptor α and Rev-erbα mediate the species-specific regulation of apolipoprotein AI expression by …
N Vu-Dac, S Chopin-Delannoy, P Gervois… - Journal of Biological …, 1998 - ASBMB
Fibrates are widely used hypolipidemic drugs which activate the nuclear peroxisome
proliferator-activated receptor (PPAR) α and thereby alter the transcription of genes
controlling lipoprotein metabolism. Fibrates influence plasma high density lipoprotein and its
major protein, apolipoprotein (apo) AI, in an opposite manner in man (increase) versus
rodents (decrease). In the present study we studied the molecular mechanisms of this
species-specific regulation of apoA-I expression by fibrates. In primary rat and human …
proliferator-activated receptor (PPAR) α and thereby alter the transcription of genes
controlling lipoprotein metabolism. Fibrates influence plasma high density lipoprotein and its
major protein, apolipoprotein (apo) AI, in an opposite manner in man (increase) versus
rodents (decrease). In the present study we studied the molecular mechanisms of this
species-specific regulation of apoA-I expression by fibrates. In primary rat and human …