[HTML][HTML] Insulin and exercise decrease glycogen synthase kinase-3 activity by different mechanisms in rat skeletal muscle
JF Markuns, JFP Wojtaszewski, LJ Goodyear - Journal of Biological …, 1999 - ASBMB
Glycogen synthase activity is increased in response to insulin and exercise in skeletal
muscle. Part of the mechanism by which insulin stimulates glycogen synthesis may involve
phosphorylation and activation of Akt, serine phosphorylation and deactivation of glycogen
synthase kinase-3 (GSK-3), leading to dephosphorylation and activation of glycogen
synthase. To study Akt and GSK-3 regulation in muscle, time course experiments on the
effects of insulin injection and treadmill running exercise were performed in hindlimb …
muscle. Part of the mechanism by which insulin stimulates glycogen synthesis may involve
phosphorylation and activation of Akt, serine phosphorylation and deactivation of glycogen
synthase kinase-3 (GSK-3), leading to dephosphorylation and activation of glycogen
synthase. To study Akt and GSK-3 regulation in muscle, time course experiments on the
effects of insulin injection and treadmill running exercise were performed in hindlimb …