[HTML][HTML] Characterization of the region involved in CD3 pairwise interactions within the T cell receptor complex
A Borroto, A Mallabiabarrena, JP Albar… - Journal of Biological …, 1998 - ASBMB
Assembly of the six-chain T cell antigen receptor-CD3 complex takes place by pairwise
interactions. Thus, CD3-ε interacts with either CD3-γ or CD3-δ, and these dimers then
associate with the TCR heterodimer (α· β or γ· δ) and the CD3-ζ homodimer to constitute a
full complex. We have now mapped the site in CD3-ε responsible for the interaction with
CD3-γ and CD3-δ by analysis of a series of deletional mutants encompassing the most
conserved regions. We found that the highly conserved juxtamembrane domain is mainly …
interactions. Thus, CD3-ε interacts with either CD3-γ or CD3-δ, and these dimers then
associate with the TCR heterodimer (α· β or γ· δ) and the CD3-ζ homodimer to constitute a
full complex. We have now mapped the site in CD3-ε responsible for the interaction with
CD3-γ and CD3-δ by analysis of a series of deletional mutants encompassing the most
conserved regions. We found that the highly conserved juxtamembrane domain is mainly …