[HTML][HTML] Association of plasma lipids and apolipoproteins with the insulin response element in the apoC-III promoter region in familial combined hyperlipidemia
M Groenendijk, RM Cantor, N Blom, JI Rotter… - Journal of lipid …, 1999 - ASBMB
Abstract The apoAI-CIII-AIV gene cluster, located on chromosome 11, contributes to the
phenotype of familial combined hyperlipidemia (FCH), but this contribution is genetically
complex. Combinations of haplotypes, based on three restriction enzyme polymorphisms:
XmnI and MspI sites, 5′ of the start site of the apoA-I gene and SstI polymorphism in the 3′
untranslated region of exon 4 of the apoC-III gene, were analyzed to characterize their effect
on the expression of severe hyperlipidemia. An epistatic interaction was demonstrated: the …
phenotype of familial combined hyperlipidemia (FCH), but this contribution is genetically
complex. Combinations of haplotypes, based on three restriction enzyme polymorphisms:
XmnI and MspI sites, 5′ of the start site of the apoA-I gene and SstI polymorphism in the 3′
untranslated region of exon 4 of the apoC-III gene, were analyzed to characterize their effect
on the expression of severe hyperlipidemia. An epistatic interaction was demonstrated: the …