[HTML][HTML] Interaction with podocin facilitates nephrin signaling
Mutations of NPHS1 or NPHS2, the genes encoding for the glomerular podocyte proteins
nephrin and podocin, cause steroid-resistant proteinuria. In addition, mice lacking CD2-
associated protein (CD2AP) develop a nephrotic syndrome that resembles NPHS mutations
suggesting that all three proteins are essential for the integrity of glomerular podocytes.
Although the precise glomerular function of either protein remains unknown, it has been
suggested that nephrin forms zipper-like interactions to maintain the structure of podocyte …
nephrin and podocin, cause steroid-resistant proteinuria. In addition, mice lacking CD2-
associated protein (CD2AP) develop a nephrotic syndrome that resembles NPHS mutations
suggesting that all three proteins are essential for the integrity of glomerular podocytes.
Although the precise glomerular function of either protein remains unknown, it has been
suggested that nephrin forms zipper-like interactions to maintain the structure of podocyte …