Thrombin-induced interleukin-8 production and its regulation by interferon-γ and prostaglandin E2 in human monocytic U937 cells
K Suk, S Cha - Immunology letters, 1999 - Elsevier
Blood coagulation and inflammation pathways are linked in many aspects. A number of
serum factors involved in coagulation cascades affect directly or indirectly inflammatory
responses, whereas proinflammatory cytokines influence blood coagulation pathways. In
this work we demonstrated that thrombin is an effective stimulus in inducing interleukin (IL)-8
expression in human monocytic cell line U937. IL-8 induction was found at the mRNA and
protein levels. The effect of thrombin on IL-8 production was mimicked by thrombin receptor …
serum factors involved in coagulation cascades affect directly or indirectly inflammatory
responses, whereas proinflammatory cytokines influence blood coagulation pathways. In
this work we demonstrated that thrombin is an effective stimulus in inducing interleukin (IL)-8
expression in human monocytic cell line U937. IL-8 induction was found at the mRNA and
protein levels. The effect of thrombin on IL-8 production was mimicked by thrombin receptor …