[HTML][HTML] Structural and functional basis of the serine protease-like hepatocyte growth factor β-chain in Met binding and signaling
D Kirchhofer, X Yao, M Peek, C Eigenbrot… - Journal of Biological …, 2004 - ASBMB
Hepatocyte growth factor (HGF), a plasminogen-related growth factor, is the ligand for Met, a
receptor tyrosine kinase implicated in development, tissue regeneration, and invasive tumor
growth. HGF acquires signaling activity only upon proteolytic cleavage of single-chain HGF
into its α/β heterodimer, similar to zymogen activation of structurally related serine proteases.
Although both chains are required for activation, only the α-chain binds Met with high affinity.
Recently, we reported that the protease-like HGF β-chain binds to Met with low affinity …
receptor tyrosine kinase implicated in development, tissue regeneration, and invasive tumor
growth. HGF acquires signaling activity only upon proteolytic cleavage of single-chain HGF
into its α/β heterodimer, similar to zymogen activation of structurally related serine proteases.
Although both chains are required for activation, only the α-chain binds Met with high affinity.
Recently, we reported that the protease-like HGF β-chain binds to Met with low affinity …