Hepatocyte growth factor (HGF) is the prototype of a family of structurally related soluble
molecules, named scatter factors (SFs). These control a complex genetic programme
leading to cell-dissociation, migration in the extracellular matrix, growth, acquisition of
polarity and tubule formation. This programme is pivotal during the embryonic development
of epithelial and some mesodermal-derived tissues. In the adult HGF sustains cell survival
and regeneration. A structurally related molecule, originally identified as macrophage …