NKT cells—conductors of tumor immunity?
MJ Smyth, NY Crowe, Y Hayakawa, K Takeda… - Current opinion in …, 2002 - Elsevier
MJ Smyth, NY Crowe, Y Hayakawa, K Takeda, H Yagita, DI Godfrey
Current opinion in immunology, 2002•ElsevierNKT cells are key players in the regulation of antitumor immunity, particularly in
experimental models of tumor immunotherapy, such as IL-12 or α-galactosylceramide
administration. They may also operate in natural antitumor immunity. NKT cells are best
known for their immunosuppressive functions; however, NKT cells interact with a range of
other cell types (particularly dendritic cells and NK cells) and the outcome of NKT-cell
stimulation depends on these and on the cytokine/co-stimulatory milieu.
experimental models of tumor immunotherapy, such as IL-12 or α-galactosylceramide
administration. They may also operate in natural antitumor immunity. NKT cells are best
known for their immunosuppressive functions; however, NKT cells interact with a range of
other cell types (particularly dendritic cells and NK cells) and the outcome of NKT-cell
stimulation depends on these and on the cytokine/co-stimulatory milieu.
NKT cells are key players in the regulation of antitumor immunity, particularly in experimental models of tumor immunotherapy, such as IL-12 or α-galactosylceramide administration. They may also operate in natural antitumor immunity. NKT cells are best known for their immunosuppressive functions; however, NKT cells interact with a range of other cell types (particularly dendritic cells and NK cells) and the outcome of NKT-cell stimulation depends on these and on the cytokine/co-stimulatory milieu.
Elsevier