Genetics of HDL regulation in humans
M Miller, J Rhyne, S Hamlette, J Birnbaum… - Current opinion in …, 2003 - journals.lww.com
M Miller, J Rhyne, S Hamlette, J Birnbaum, A Rodriguez
Current opinion in lipidology, 2003•journals.lww.comDisorders affecting HDL metabolism are complex because monogenic disorders causing
low HDL do not necessarily correlate with premature vascular disease. To date, pathologic
phenotypes have only been deduced among several HDL candidate genes. Understanding
the genetic underpinnings associated with variant HDL and reverse cholesterol transport
provides an exceptional opportunity to identify novel agents that may optimize this process
and reduce vascular event rates beyond currently available LDL lowering therapies.
low HDL do not necessarily correlate with premature vascular disease. To date, pathologic
phenotypes have only been deduced among several HDL candidate genes. Understanding
the genetic underpinnings associated with variant HDL and reverse cholesterol transport
provides an exceptional opportunity to identify novel agents that may optimize this process
and reduce vascular event rates beyond currently available LDL lowering therapies.
Summary
Disorders affecting HDL metabolism are complex because monogenic disorders causing low HDL do not necessarily correlate with premature vascular disease. To date, pathologic phenotypes have only been deduced among several HDL candidate genes. Understanding the genetic underpinnings associated with variant HDL and reverse cholesterol transport provides an exceptional opportunity to identify novel agents that may optimize this process and reduce vascular event rates beyond currently available LDL lowering therapies.
Lippincott Williams & Wilkins