[HTML][HTML] Bmi1, stem cells, and senescence regulation
IK Park, SJ Morrison, MF Clarke - The Journal of clinical …, 2004 - Am Soc Clin Investig
IK Park, SJ Morrison, MF Clarke
The Journal of clinical investigation, 2004•Am Soc Clin InvestigStem cells generate the differentiated cell types within many organs throughout the lifespan
of an organism and are thus ultimately responsible for the longevity of multicellular
organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the
maintenance of adult stem cells in some tissues partly because it represses genes that
induce cellular senescence and cell death.
of an organism and are thus ultimately responsible for the longevity of multicellular
organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the
maintenance of adult stem cells in some tissues partly because it represses genes that
induce cellular senescence and cell death.
Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.
The Journal of Clinical Investigation