A low polymorphic mouse H-2 class I gene from the Tla complex is expressed in a broad variety of cell types.
C Transy, SR Nash, B David-Watine… - The Journal of …, 1987 - rupress.org
C Transy, SR Nash, B David-Watine, M Cochet, SW Hunt 3rd, LE Hood, P Kourilsky
The Journal of experimental medicine, 1987•rupress.orgWe have previously described the isolation of pH-2d-37, a cDNA clone that encodes a so far
unknown, poorly polymorphic, class I surface molecule. We report here the isolation of the
corresponding gene, its nucleotide sequence, and its localization in the Tla region of the
murine MHC. Using a RNase mapping assay, we have confirmed that the second domain
coding region of the 37 gene displays very limited polymorphism, and that the gene is
transcribed in a broad variety of cell types, in contrast to the genes encoding the known Qa …
unknown, poorly polymorphic, class I surface molecule. We report here the isolation of the
corresponding gene, its nucleotide sequence, and its localization in the Tla region of the
murine MHC. Using a RNase mapping assay, we have confirmed that the second domain
coding region of the 37 gene displays very limited polymorphism, and that the gene is
transcribed in a broad variety of cell types, in contrast to the genes encoding the known Qa …
We have previously described the isolation of pH-2d-37, a cDNA clone that encodes a so far unknown, poorly polymorphic, class I surface molecule. We report here the isolation of the corresponding gene, its nucleotide sequence, and its localization in the Tla region of the murine MHC. Using a RNase mapping assay, we have confirmed that the second domain coding region of the 37 gene displays very limited polymorphism, and that the gene is transcribed in a broad variety of cell types, in contrast to the genes encoding the known Qa and TL antigens. Possible functions are discussed.
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