Expression of class I genes in the major histocompatibility complex: identification of eight distinct mRNAs in DBA/2 mouse liver
JL Lalanne, C Transy, S Guerin, S Darche, P Meulien… - Cell, 1985 - cell.com
JL Lalanne, C Transy, S Guerin, S Darche, P Meulien, P Kourilsky
Cell, 1985•cell.comThe mouse H-2 multigene family includes the genes coding for the major transplantation
antigens and for genes located in the Qa-Tla region. We have studied a collection of class I
cDNA clones made from liver mRNA of DBA/2 mice (H-2 d haplotype) and found that at least
six distinct class I genes are transcribed, including three genes of the QaTla region. Two of
these six genes each yield two distinct mRNAs, resulting from alternate splicing. Altogether,
liver cells may express at least eight distinct class I polypeptides, of which three might be …
antigens and for genes located in the Qa-Tla region. We have studied a collection of class I
cDNA clones made from liver mRNA of DBA/2 mice (H-2 d haplotype) and found that at least
six distinct class I genes are transcribed, including three genes of the QaTla region. Two of
these six genes each yield two distinct mRNAs, resulting from alternate splicing. Altogether,
liver cells may express at least eight distinct class I polypeptides, of which three might be …
Summary
The mouse H-2 multigene family includes the genes coding for the major transplantation antigens and for genes located in the Qa-Tla region. We have studied a collection of class I cDNA clones made from liver mRNA of DBA/2 mice (H-2d haplotype) and found that at least six distinct class I genes are transcribed, including three genes of the QaTla region. Two of these six genes each yield two distinct mRNAs, resulting from alternate splicing. Altogether, liver cells may express at least eight distinct class I polypeptides, of which three might be secreted, while one may be a new presumptive nonpolymorphic surface antigen.
cell.com