A new serologically defined locus,Qa-1, in theTla-region of the mouse
TH Stanton, EA Boyse - Immunogenetics, 1976 - Springer
TH Stanton, EA Boyse
Immunogenetics, 1976•SpringerA new cell-surface antigen, specified by a gene between H-2D and Tla is described. The
provisional notation Qa-1 is suggested for the locus determining this newly recognized cell
surface component. Qa-1 is distinguished from known TL antigens by the following two
criteria. Its expression is not confined to thymocytes—it occurs on lymph node cells (LNC)
also; and the phenotypes of the new congenic recombinant strains B6. K1 and B6. K2,
derived from H-2D/Tla crossovers, are Qa-1+ Qa-2− TL− and Qa-l+ Qa-2+ TL−. Qa-1 antigen …
provisional notation Qa-1 is suggested for the locus determining this newly recognized cell
surface component. Qa-1 is distinguished from known TL antigens by the following two
criteria. Its expression is not confined to thymocytes—it occurs on lymph node cells (LNC)
also; and the phenotypes of the new congenic recombinant strains B6. K1 and B6. K2,
derived from H-2D/Tla crossovers, are Qa-1+ Qa-2− TL− and Qa-l+ Qa-2+ TL−. Qa-1 antigen …
Abstract
A new cell-surface antigen, specified by a gene betweenH-2D andTla is described. The provisional notationQa-1 is suggested for the locus determining this newly recognized cell surface component. Qa-1 is distinguished from known TL antigens by the following two criteria. Its expression is not confined to thymocytes — it occurs on lymph node cells (LNC) also; and the phenotypes of the new congenic recombinant strains B6.K1 and B6.K2, derived fromH-2D/Tla crossovers, are Qa-1+ Qa-2−TL− and Qa-l+Qa-2+TL−. Qa-1 antigen is defined by reaction of the standard TL typing serum, (B6 × A -Tla b)F1 anti-A strain leukemia ASL1, with lymph node cells (LNC) in the cytotoxicity assay. Qa-1 antigen evidently is expressed, at least, on a subpopulation of T cells as well as on thymocytes. The gene order isH-2D, Qa-1, Qa-2, Tla.
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