Less Mortality but More Relapses in Experimental Allergic Encephalomyelitis in CD8-/- Mice
DR Koh, WP Fung-Leung, A Ho, D Gray, H Acha-Orbea… - Science, 1992 - science.org
DR Koh, WP Fung-Leung, A Ho, D Gray, H Acha-Orbea, TW Mak
Science, 1992•science.orgMice lacking in CD8 were generated from homologous recombination in embryonal stem
cells at the CD8 locus and bred with the experimental allergic encephalomyelitis (EAE)
susceptible PL/J H-2u through four backcross generations to investigate the role of CD8+ T
cells in this model of multiple sclerosis. The disease onset and susceptibility were similar to
those of wild-type mice. However, the mutant mice had a milder acute EAE, reflected by
fewer deaths, but more chronic EAE, reflected by a higher frequency of relapse. This …
cells at the CD8 locus and bred with the experimental allergic encephalomyelitis (EAE)
susceptible PL/J H-2u through four backcross generations to investigate the role of CD8+ T
cells in this model of multiple sclerosis. The disease onset and susceptibility were similar to
those of wild-type mice. However, the mutant mice had a milder acute EAE, reflected by
fewer deaths, but more chronic EAE, reflected by a higher frequency of relapse. This …
Mice lacking in CD8 were generated from homologous recombination in embryonal stem cells at the CD8 locus and bred with the experimental allergic encephalomyelitis (EAE)susceptible PL/J H-2u through four backcross generations to investigate the role of CD8+ T cells in this model of multiple sclerosis. The disease onset and susceptibility were similar to those of wild-type mice. However, the mutant mice had a milder acute EAE, reflected by fewer deaths, but more chronic EAE, reflected by a higher frequency of relapse. This suggests that CD8+ T lymphocytes may participate as both effectors and regulators in this animal model.
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