The role of different subsets of T regulatory cells in controlling autoimmunity
MG Roncarolo, MK Levings - Current opinion in immunology, 2000 - Elsevier
MG Roncarolo, MK Levings
Current opinion in immunology, 2000•ElsevierT regulatory cells—in addition to clonal deletion and anergy—are essential for the
downregulation of T cell responses to both foreign and self antigens, and for the prevention
of autoimmunity. Recent progress has been made in characterising the different subsets of T
regulatory cells, the factors that drive their differentiation, and their mode of action. The
resolution of these mechanisms will make it possible to use T regulatory cells therapeutically
in human autoimmune diseases.
downregulation of T cell responses to both foreign and self antigens, and for the prevention
of autoimmunity. Recent progress has been made in characterising the different subsets of T
regulatory cells, the factors that drive their differentiation, and their mode of action. The
resolution of these mechanisms will make it possible to use T regulatory cells therapeutically
in human autoimmune diseases.
T regulatory cells—in addition to clonal deletion and anergy—are essential for the downregulation of T cell responses to both foreign and self antigens, and for the prevention of autoimmunity. Recent progress has been made in characterising the different subsets of T regulatory cells, the factors that drive their differentiation, and their mode of action. The resolution of these mechanisms will make it possible to use T regulatory cells therapeutically in human autoimmune diseases.
Elsevier