A defect in interleukin 12–induced activation and interferon γ secretion of peripheral natural killer T cells in nonobese diabetic mice suggests new pathogenic …
M Falcone, B Yeung, L Tucker, E Rodriguez… - The Journal of …, 1999 - rupress.org
M Falcone, B Yeung, L Tucker, E Rodriguez, N Sarvetnick
The Journal of experimental medicine, 1999•rupress.orgThe function of natural killer T (NKT) cells in the immune system has yet to be determined.
There is some evidence that their defect is associated with autoimmunity, but it is still unclear
how they play a role in regulating the pathogenesis of T cell–mediated autoimmune
diseases. It was originally proposed that NKT cells could control autoimmunity by shifting the
cytokine profile of autoimmune T cells toward a protective T helper 2 cell (Th2) type.
However, it is now clear that the major function of NKT cells in the immune system is not …
There is some evidence that their defect is associated with autoimmunity, but it is still unclear
how they play a role in regulating the pathogenesis of T cell–mediated autoimmune
diseases. It was originally proposed that NKT cells could control autoimmunity by shifting the
cytokine profile of autoimmune T cells toward a protective T helper 2 cell (Th2) type.
However, it is now clear that the major function of NKT cells in the immune system is not …
The function of natural killer T (NKT) cells in the immune system has yet to be determined. There is some evidence that their defect is associated with autoimmunity, but it is still unclear how they play a role in regulating the pathogenesis of T cell–mediated autoimmune diseases. It was originally proposed that NKT cells could control autoimmunity by shifting the cytokine profile of autoimmune T cells toward a protective T helper 2 cell (Th2) type. However, it is now clear that the major function of NKT cells in the immune system is not related to their interleukin (IL)-4 secretion. In fact, NKT cells mainly secrete interferon (IFN)-γ and, activated in the presence of IL-12, acquire a strong inflammatory phenotype and cytotoxic function.
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