von Hippel-Lindau gene deletion detected in the stromal cell component of a cerebellar hemangioblastoma associated with von Hippel-Lindau disease
Central nervous system hemangioblastoma is a neoplasm with characteristic and well-
described histopathological features, including proliferation of vascular and stromal cells.
Yet, the histogenesis of the stromal cell component and its neoplastic capacity as compared
with the vascular component are still controversial. Stromal cells were selectively procured
from formalin-fixed, paraffin-embedded archival tissue from a von Hippel-Lindau (VHL)
disease patient with a cerebellar hemangioblastoma and studied for loss of heterozygosity …
described histopathological features, including proliferation of vascular and stromal cells.
Yet, the histogenesis of the stromal cell component and its neoplastic capacity as compared
with the vascular component are still controversial. Stromal cells were selectively procured
from formalin-fixed, paraffin-embedded archival tissue from a von Hippel-Lindau (VHL)
disease patient with a cerebellar hemangioblastoma and studied for loss of heterozygosity …