Inhibition by nitric oxide and nitric oxide-producing vasodilators of DNA synthesis in vascular smooth muscle cells
T Nakaki, M Nakayama, R Kato - European Journal of Pharmacology …, 1990 - Elsevier
Abstract Effects of nitric oxide (NO) and NO-producing vasodilators such as glyceryl trinitrate
and sodium nitroprusside were tested on DNA synthesis in the clonal rajortic smooth muscle
cells. RACS-1. DNA synthesis was estimated by [3 H] thymidine incorporation to DNA, NO
and NO-producing vasodilators inhibited the DNA synthesis that was induced by 10% fetal
calf serum. NO and NO-producing vasodilators also inhibited the basal level of DNA
synthesis that occurred possibly as a result of autocrine mechanisms. NO-producing …
and sodium nitroprusside were tested on DNA synthesis in the clonal rajortic smooth muscle
cells. RACS-1. DNA synthesis was estimated by [3 H] thymidine incorporation to DNA, NO
and NO-producing vasodilators inhibited the DNA synthesis that was induced by 10% fetal
calf serum. NO and NO-producing vasodilators also inhibited the basal level of DNA
synthesis that occurred possibly as a result of autocrine mechanisms. NO-producing …