[HTML][HTML] Brain metabolism during fasting

OE Owen, AP Morgan, HG Kemp… - The Journal of …, 1967 - Am Soc Clin Investig
OE Owen, AP Morgan, HG Kemp, JM Sullivan, MG Herrera, GFJ Cahill
The Journal of clinical investigation, 1967Am Soc Clin Investig
Catheterization of cerebral vessels in three obese patients undergoing 5-6 wk of starvation
demonstrated that β-hydroxybutyrate and acetoacetate replaced glucose as the
predominant fuel for brain metabolism. A strikingly low respiratory quotient was also
observed, suggesting a carboxylation mechanism as a means of disposing of some of the
carbon of the consumed substrates.
Catheterization of cerebral vessels in three obese patients undergoing 5-6 wk of starvation demonstrated that β-hydroxybutyrate and acetoacetate replaced glucose as the predominant fuel for brain metabolism. A strikingly low respiratory quotient was also observed, suggesting a carboxylation mechanism as a means of disposing of some of the carbon of the consumed substrates.
The Journal of Clinical Investigation