Mechanism of action of thrombin on platelets

HJ Schmid, DP Jackson… - The Journal of Clinical …, 1962 - Am Soc Clin Investig
HJ Schmid, DP Jackson, CL Conley
The Journal of Clinical Investigation, 1962Am Soc Clin Investig
Baltimore, Md.) Page 1 Journal of Clinical Investigation Vol. 41, No. 3, 1962 MECHANISM OF
ACTION OF THROMBIN ON PLATELETS * BY HANS J. SCHMID, DUDLEY P. JACKSON AND
C. LOCKARD CONLEY (From the Department of Medicine of The Johns Hopkins University
and Hospital, Baltimore, Md.) (Submitted for publication September 8, 1961; accepted October
9, 1961) Thrombin, a proteolytic enzyme, is known to initiate certain reactions of platelets
including aggregation (1), retraction of clots (2), and release of serotonin (3). Thrombin …
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