[PDF][PDF] The renal clearances of substituted hippuric acid derivatives and other aromatic acids in dog and man
HW Smith, N Finkelstein, L Aliminosa… - The Journal of …, 1945 - Am Soc Clin Investig
HW Smith, N Finkelstein, L Aliminosa, B Crawford, M Graber
The Journal of clinical investigation, 1945•Am Soc Clin InvestigCX/CCrl CY/CCr2 (where Cc,, is the creatinine clearance in the first 3 periods and CCr2 the
cre-atinine clearance in the second 3 periods). Alternatively, the inulin (CIN) or mannitol
(Cm) clear-ance ratio is used for this purpose in man. Here errors in timing and urine
collection affect Cx and Ccy1 (or Cy and CCr2) equally and hence cancel out. Moreover, in
the dog the filtrationrate, Ccr, tends to varywith the renal plasma flow, Cx (or Cy where Cy is
approximately equal to Cx), the filtration fraction Ccr/Cx changing only slightly with marked …
cre-atinine clearance in the second 3 periods). Alternatively, the inulin (CIN) or mannitol
(Cm) clear-ance ratio is used for this purpose in man. Here errors in timing and urine
collection affect Cx and Ccy1 (or Cy and CCr2) equally and hence cancel out. Moreover, in
the dog the filtrationrate, Ccr, tends to varywith the renal plasma flow, Cx (or Cy where Cy is
approximately equal to Cx), the filtration fraction Ccr/Cx changing only slightly with marked …
CX/CCrl CY/CCr2 (where Cc,, is the creatinine clearance in the first 3 periods and CCr2 the cre-atinine clearance in the second 3 periods). Alternatively, the inulin (CIN) or mannitol (Cm) clear-ance ratio is used for this purpose in man. Here errors in timing and urine collection affect Cx and Ccy1 (or Cy and CCr2) equally and hence cancel out.
Moreover, in the dog the filtrationrate, Ccr, tends to varywith the renal plasma flow, Cx (or Cy where Cy is approximately equal to Cx), the filtration fraction Ccr/Cx changing only slightly with marked changes in Cx. Consequently, changes in the renal plasma flow tend to be eliminated when one compares the successive clearance ratios. Indeed, for the dog, we consider this to be a much more accurate method of comparison than method 1.
The Journal of Clinical Investigation