[HTML][HTML] Signal transduction by the CEACAM1 tumor suppressor: phosphorylation of serine 503 is required for growth-inhibitory activity
VT Estrera, DT Chen, W Luo, DC Hixson… - Journal of Biological …, 2001 - ASBMB
CEACAM1 is a cell-cell adhesion molecule that mediates homophilic cell adhesion. In
addition, CEACAM1 was also shown to suppress the growth of prostate, breast, and colon
tumors. Structural and functional analyses showed that the adhesion activity of CEACAM1 is
mediated by its extracellular domain while its cytoplasmic domain is necessary and sufficient
for growth-inhibitory activity. The signal pathways leading to CEACAM1-mediated growth
suppression are not known. We studied the importance of phosphorylation of serine 503 in …
addition, CEACAM1 was also shown to suppress the growth of prostate, breast, and colon
tumors. Structural and functional analyses showed that the adhesion activity of CEACAM1 is
mediated by its extracellular domain while its cytoplasmic domain is necessary and sufficient
for growth-inhibitory activity. The signal pathways leading to CEACAM1-mediated growth
suppression are not known. We studied the importance of phosphorylation of serine 503 in …