[HTML][HTML] Insulin secretory deficiency and glucose intolerance in Rab3A null mice

K Yaekura, R Julyan, BL Wicksteed, LB Hays… - Journal of Biological …, 2003 - ASBMB
Insulin secretory dysfunction of the pancreatic β-cell in type-2 diabetes is thought to be due
to defective nutrient sensing and/or deficiencies in the mechanism of insulin exocytosis.
Previous studies have indicated that the GTP-binding protein, Rab3A, plays a mechanistic
role in insulin exocytosis. Here, we report that Rab3A−/− mice develop fasting
hyperglycemia and upon a glucose challenge show significant glucose intolerance coupled
to ablated first-phase insulin release and consequential insufficient insulin secretion in vivo …