Involvement of the Tpl-2/cot oncogene in MMTV tumorigenesis.

KM Erny, J Peli, JF Lambert, V Muller, H Diggelmann - Oncogene, 1996 - europepmc.org
KM Erny, J Peli, JF Lambert, V Muller, H Diggelmann
Oncogene, 1996europepmc.org
We report for the first time a relationship between the Tpl-2/cot oncogene and Mouse
Mammary Tumor Virus (MMTV) associated transformation of mammary gland cells. A sub-
genomic library generated from a primary mammary gland tumor yielded a novel MMTV
integration site which disrupted the Tpl-2/cot proto-oncogene between exons 7 and 8.
Comparison of a cell line derived from normal mammary gland (comma-D) and a cell line
established from an MMTV induced mammary tumor (GR) demonstrated similar …
We report for the first time a relationship between the Tpl-2/cot oncogene and Mouse Mammary Tumor Virus (MMTV) associated transformation of mammary gland cells. A sub-genomic library generated from a primary mammary gland tumor yielded a novel MMTV integration site which disrupted the Tpl-2/cot proto-oncogene between exons 7 and 8. Comparison of a cell line derived from normal mammary gland (comma-D) and a cell line established from an MMTV induced mammary tumor (GR) demonstrated similar rearrangements within Tpl-2/cot for the GR cells but not in the comma-D cells. These rearrangements in the cell line were accompanied by an increase in the level of Tpl-2/cot specific mRNA. This data suggests that Tpl-2/cot expression may be important in epithelial cell transformation or tumor progression.
europepmc.org