The Density of the Class II MHC T Cell Receptor Ligand Influences IFN-γ/IL-4 Ratios in Immune Responsesin Vivo
L DiMolfetto, HA Neal, A Wu, C Reilly, D Lo - Cellular immunology, 1998 - Elsevier
Activation of CD4+ T cells depends on T cell receptor recognition of MHC class II/peptide
and on costimulation provided by CD28/B7. It has been shown that different levels of
costimulation can influence T helper cell differentiation into Th1 versus Th2 phenotypes.
Similar arguments have been made for different levels of peptide/MHC density on antigen-
presenting cells, but to date supportive evidence has only come fromin vitrostudies. Here,
using transgenic mice with reduced MHC class II expression on both B cells and dendritic …
and on costimulation provided by CD28/B7. It has been shown that different levels of
costimulation can influence T helper cell differentiation into Th1 versus Th2 phenotypes.
Similar arguments have been made for different levels of peptide/MHC density on antigen-
presenting cells, but to date supportive evidence has only come fromin vitrostudies. Here,
using transgenic mice with reduced MHC class II expression on both B cells and dendritic …