Overexpression of low density lipoprotein receptor eliminates apolipoprotein B100-containing lipoproteins from circulation and markedly prevents early atherogenesis …

T Murayama, M Yokode, H Horiuchi, H Yoshida… - Atherosclerosis, 2000 - Elsevier
Apolipoprotein E (ApoE) plays a pivotal role in the metabolism of apolipoprotein B (apoB)-
containing lipoproteins. The defective apoE gene in humans can cause elevated plasma
levels of apoB-containing lipoproteins such as chylomicron remnant and intermediate
density lipoprotein (IDL). In this study, we examined whether liver-selective high-level
expression of low-density lipoprotein receptor (LDLR) could affect the lipoprotein profile and
atherogenesis in apoE-deficient (apoE−/−) mice. ApoE knockout mice expressing LDLR …