[HTML][HTML] Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible …
S Chakraborty, V Senyuk, S Sitailo, Y Chi… - Journal of Biological …, 2001 - ASBMB
EVI1 is a very complex protein with two domains of zinc fingers and is inappropriately
expressed in many types of human myeloid leukemias. Using reporter gene assays, several
investigators showed that EVI1 is a transcription repressor, and recently it was shown that
EVI1 interacts with the co-repressor carboxyl-terminal binding protein 1 (CtBP1). Earlier, we
showed that the inappropriate expression of EVI1 in murine hematopoietic precursor cells
leads to their abnormal differentiation and to increased proliferation. Using biochemical …
expressed in many types of human myeloid leukemias. Using reporter gene assays, several
investigators showed that EVI1 is a transcription repressor, and recently it was shown that
EVI1 interacts with the co-repressor carboxyl-terminal binding protein 1 (CtBP1). Earlier, we
showed that the inappropriate expression of EVI1 in murine hematopoietic precursor cells
leads to their abnormal differentiation and to increased proliferation. Using biochemical …