[HTML][HTML] Full oncogenic activities of v-Src are mediated by multiple signaling pathways: Ras as an essential mediator for cell survival
J Odajima, I Matsumura, J Sonoyama, H Daino… - Journal of Biological …, 2000 - ASBMB
Tyrosine kinase oncoproteins cause simultaneous activation of multiple intracellular
signaling pathways. However, the precise mechanisms by which individual pathways induce
oncogenesis are not well understood. We have investigated the roles of individual signaling
pathways in v-Src-dependent cell growth and survival by inhibiting one particular pathway. v-
Src induced constitutive activation of signal transducers and activators of transcription 3
(STAT3), phosphatidylinositol 3-kinase, and Ras in murine Ba/F3 cells and led to factor …
signaling pathways. However, the precise mechanisms by which individual pathways induce
oncogenesis are not well understood. We have investigated the roles of individual signaling
pathways in v-Src-dependent cell growth and survival by inhibiting one particular pathway. v-
Src induced constitutive activation of signal transducers and activators of transcription 3
(STAT3), phosphatidylinositol 3-kinase, and Ras in murine Ba/F3 cells and led to factor …