Human immunodeficiency virus-1 induces loss of contact inhibition in podocytes
EJ Schwartz, A Cara, H Snoeck, MD Ross… - Journal of the …, 2001 - journals.lww.com
Human immunodeficiency virus—associated nephropathy (HIVAN) affects up to 10% of HIV-
positive black adults and children and is the leading cause of renal disease in infected
individuals. The disease is characterized by proliferation of renal epithelial cells, both
glomerular and tubular. Diseased kidneys are enlarged, and glomerular visceral epithelial
cells (podocytes) express proliferation markers. In a transgenic murine model of HIVAN
expressing a deletion construct of HIV-1, the identical pathologic features are observed. It …
positive black adults and children and is the leading cause of renal disease in infected
individuals. The disease is characterized by proliferation of renal epithelial cells, both
glomerular and tubular. Diseased kidneys are enlarged, and glomerular visceral epithelial
cells (podocytes) express proliferation markers. In a transgenic murine model of HIVAN
expressing a deletion construct of HIV-1, the identical pathologic features are observed. It …