Bisphosphonates are potent inhibitors of osteoclast function widely used to treat conditions
of excessive bone resorption, including tumor bone metastases. Recent evidence indicates
that bisphosphonates have direct cytotoxic activity on tumor cells and suppress
angiogenesis, but the associated molecular events have not been fully characterized. In this
study we investigated the effects of zoledronate, a nitrogen-containing bisphosphonate, and
clodronate, a non-nitrogen-containing bisphosphonate, on human umbilical vein endothelial …