Mouse models for multistep tumorigenesis

X Wu, PP Pandolfi - Trends in cell biology, 2001 - cell.com
Trends in cell biology, 2001cell.com
The mouse is an ideal model system for studying the molecular mechanisms underlying the
pathogenesis of human cancer. The generation of transgenic and gene-knockout mice has
been instrumental in determining the role of major determinants in this process, such as
oncogenes and tumor-suppressor genes. In the past few years, modeling cancer in the
mouse has increased in its complexity, allowing in vivo dissection of the fundamental
concepts underlying cooperative oncogenesis in various tumor types. In this review, we …
Abstract
The mouse is an ideal model system for studying the molecular mechanisms underlying the pathogenesis of human cancer. The generation of transgenic and gene-knockout mice has been instrumental in determining the role of major determinants in this process, such as oncogenes and tumor-suppressor genes. In the past few years, modeling cancer in the mouse has increased in its complexity, allowing in vivo dissection of the fundamental concepts underlying cooperative oncogenesis in various tumor types. In this review, we discuss how this transition has been facilitated, providing relevant examples. We also review how, in the post-genome era, novel methodologies will further accelerate the study of multi-step tumorigenesis in the mouse.
cell.com