[HTML][HTML] Osteopontin stimulates tumor growth and activation of promatrix metalloproteinase-2 through nuclear factor-κB-mediated induction of membrane type 1 matrix …
S Philip, A Bulbule, GC Kundu - Journal of Biological Chemistry, 2001 - ASBMB
Matrix metalloproteinases (MMPs) degrade the extracellular matrix (ECM) and play critical
roles in tissue repair, tumor invasion, and metastasis. MMPs are regulated by different
cytokines, ECM proteins, and other factors. However, the molecular mechanisms by which
osteopontin (OPN), an ECM protein, regulates ECM invasion and tumor growth and
modulates MMP activation in B16F10 cells are not well defined. We have purified OPN from
human milk and shown that OPN induces pro-MMP-2 production and activation in these …
roles in tissue repair, tumor invasion, and metastasis. MMPs are regulated by different
cytokines, ECM proteins, and other factors. However, the molecular mechanisms by which
osteopontin (OPN), an ECM protein, regulates ECM invasion and tumor growth and
modulates MMP activation in B16F10 cells are not well defined. We have purified OPN from
human milk and shown that OPN induces pro-MMP-2 production and activation in these …