[HTML][HTML] Akt stimulates the transactivation potential of the RelA/p65 subunit of NF-κB through utilization of the IκB kinase and activation of the mitogen-activated protein …

LV Madrid, MW Mayo, JY Reuther… - Journal of Biological …, 2001 - ASBMB
The serine/threonine kinase Akt/PKB is a potent regulator of cell survival and has oncogenic
transformation potential. Previously, it has been shown that Akt can activate the transcription
factor NF-κB and that this functions to block apoptosis induced by certain stimuli. The
mechanism whereby Akt activates NF-κB has been controversial, with evidence supporting
induction of nuclear translocation of NF-κB via activation of IκB kinase activity and/or the
stimulation of the transcription function of NF-κB. Here we demonstrate that Akt targets the …